Epigenetic Modifications of Immune Cells and their Importance for Alloimmunity

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Speaker: Andrew Wells, PhD • University of Pennsylvania and CHOP
Moderator: Jonathan Maltzman, MD, PhD • Stanford University

After participating in this webinar, the learner will be able to:

1. Define epigenetics, outline basic concepts and processes.
2. Outline examples of DNA methylation controlling T cell function.
3. Outline examples of histone modifications controlling T cell function.
4. Describe examples of epigenetic factors contributing to organ transplant rejection in rodent models.
5. Describe a clinical example of epigenetic drug targeting in allogenic bone marrow transplantation to alleviate GVHD.
6. Outline basic concepts in genomics and epigenomics.
7. Describe 3-dimensional regulatory architectures of inflammatory genes in T cells.
8. Discuss the use of 3D epigenomics to understand the basis of genetic susceptibility to inflammatory disease in humans.